The Pathogenesis of Down’s Syndrome Essay -- Science Medical Genetics

The Pathogenesis of Down’s Syndrome Down’s syndrome (DS) is the most common cause of mental retardation in the United States. It occurs with a frequency of one in 700 live births. The disease is caused by the presence of three copies of chromosome 21 as a result of chromosomal mutation (95% nondisjunction, 5% translocation) during cell division, leading to a total of 47 chromosomes instead of the normal number, 46. There are no individuals with the clinical signs of DS who do not have at least partial trisomy of chromosome 21. Conversely, there are no cases of people with trisomy 21 who do not have DS (Patterson, 1987). Patients suffer from a variety of physical and mental problems. Physically, the disease manifests itself in epicanthic folds of the eyes, flattened facial features, unusual palm creases, muscular flaccidity and short stature (Patterson, 1987). Many are born with congenital heart defects and increased risk for cataracts, leukemia and Alzheimer’s disease. In addition to the anatomical abnorm alities, DS patients suffer from biochemical imbalances including elevated levels of purines - a condition that can by itself lead to neurological impairment, mental retardation, and immunodeficiencies. The life expectancy for DS patients is approximately 30 years. However, with advancing medical care and therapy more patients are living to the age of 50. All individuals with DS over the age of 35 develop the same kind of abnormal microscopic plaques and neurofibrillary tangles in the brain as people who die from Alzheimer’s disease, the major cause of presenile dementia. Although a vast amount of literature exists on DS, little is known about why the presence of an extra chromosome causes mental retardation. In addition to ... ...ogy and Experimental Neurology, 49: 509-518. Ferrer, I., Gullotta, F. (1990): Down’s Syndrome and Alzheimer’s Disease: Dendritic Spine Counts in the Hippocampus. Acta Neuropathol, 79: 680--685. Mann, D. M. A., Brown, A., Prinja, D., Davies, C. A., Landon, M., Masters, C. L., Beyreuthers, K. (1989): An Analysis of the Morphology of Senile Plaques in Down’s Syndrome Patients of Different Ages Using Immunocytochemical and Lectin Histochemical Techniques. Neuropathology and Applied Neurobiology, 15: 317-329. Patterson, D. (1987): The Causes of Down Syndrome. Scientific American, 255: 52-60. Takashima, S., Ieshima, A., Nakamura, H., Becker, L. (1989): Dendrites, Dementia and the Down Syndrome. Brain Development, 11: 131-133. Wisniewski, K., Bobinski, M. (1991): Hypothalamic Abnormalities in Down Syndrome. The Morphogenesis of Down Syndrome., 153-167. The Pathogenesis of Down’s Syndrome Essay -- Science Medical Genetics The Pathogenesis of Down’s Syndrome Down’s syndrome (DS) is the most common cause of mental retardation in the United States. It occurs with a frequency of one in 700 live births. The disease is caused by the presence of three copies of chromosome 21 as a result of chromosomal mutation (95% nondisjunction, 5% translocation) during cell division, leading to a total of 47 chromosomes instead of the normal number, 46. There are no individuals with the clinical signs of DS who do not have at least partial trisomy of chromosome 21. Conversely, there are no cases of people with trisomy 21 who do not have DS (Patterson, 1987). Patients suffer from a variety of physical and mental problems. Physically, the disease manifests itself in epicanthic folds of the eyes, flattened facial features, unusual palm creases, muscular flaccidity and short stature (Patterson, 1987). Many are born with congenital heart defects and increased risk for cataracts, leukemia and Alzheimer’s disease. In addition to the anatomical abnorm alities, DS patients suffer from biochemical imbalances including elevated levels of purines - a condition that can by itself lead to neurological impairment, mental retardation, and immunodeficiencies. The life expectancy for DS patients is approximately 30 years. However, with advancing medical care and therapy more patients are living to the age of 50. All individuals with DS over the age of 35 develop the same kind of abnormal microscopic plaques and neurofibrillary tangles in the brain as people who die from Alzheimer’s disease, the major cause of presenile dementia. Although a vast amount of literature exists on DS, little is known about why the presence of an extra chromosome causes mental retardation. In addition to ... ...ogy and Experimental Neurology, 49: 509-518. Ferrer, I., Gullotta, F. (1990): Down’s Syndrome and Alzheimer’s Disease: Dendritic Spine Counts in the Hippocampus. Acta Neuropathol, 79: 680--685. Mann, D. M. A., Brown, A., Prinja, D., Davies, C. A., Landon, M., Masters, C. L., Beyreuthers, K. (1989): An Analysis of the Morphology of Senile Plaques in Down’s Syndrome Patients of Different Ages Using Immunocytochemical and Lectin Histochemical Techniques. Neuropathology and Applied Neurobiology, 15: 317-329. Patterson, D. (1987): The Causes of Down Syndrome. Scientific American, 255: 52-60. Takashima, S., Ieshima, A., Nakamura, H., Becker, L. (1989): Dendrites, Dementia and the Down Syndrome. Brain Development, 11: 131-133. Wisniewski, K., Bobinski, M. (1991): Hypothalamic Abnormalities in Down Syndrome. The Morphogenesis of Down Syndrome., 153-167.

Apollo vs. Green Arrow

Apollo and Green Arrow/ Oliver Queen When I first learned about the Greek god Apollo in my Classical Mythology class, he reminded me of Oliver Queen. Oliver Queen is a character from one of my favorite television show called â€Å"Smallville†. He inherited a big industrial empire from his parents when they passed away. He was a playboy who did not care to give back to the society and only did what pleases him. One day, when Oliver was out on his boat, he was pushed overboard into the sea by an employee. After being marooned on an island, he learned to hunt and improved his survival skills.He later found a small settlement on the island and saw that some of the islanders were cruelly disposed of in a nearby well. It shocked him and he became focused on avenging their deaths. He resorted to making his own weapons and pursued the escaping men in the boats, who turned out to be drug dealers. His stamina and skills helped him overcome them, and was later able to turn them over to t he police. Oliver had his first taste of crime fighting then. He vowed to change the world for the better with the resources he had. He became a vigilante under the name of â€Å"Green Arrow†. â€Å"Comic Vine†) I think that Oliver Queen and Apollo seems so alike yet different at the same time. I believe that they will make a great comparison to each other. The very first and obvious similarity between Apollo and Oliver is that they are both skillful archers. Apollo is the god of Archery. When Apollo was still an infant, he claimed that the bow was his. (Mayerson 118) Oliver created his vigilante persona based on his skill and passion for arrows and bows. When he was marooned on an island, he improved his already talented archery skills.He made his own makeshift bow and arrows and used them to hunt to eat. With his refined archery skills, he later tracked down the drug dealers who were escaping in a plane. He managed to gain upper hand by shooting them down. Oliverâ₠¬â„¢s vigilante character â€Å"Green Arrow is considered by even the superhuman members of the Justice League to be the greatest archer in the world. † (â€Å"Comic Vine†) Oliver himself always said that Green Arrow never misses a target, not even when he was not looking at the target. Apollo and Oliver are also both full of wit and charm.Apollo is the God of Music. According to Mayerson, â€Å"the infant-god †¦ declared that the †¦ lyre would be his†. He later joined the other gods in Olympus and played the lyre them. Oliver is also very charming. In various episodes of Smallville I have watched, Oliver is often seen offering a glass of wine for a beautiful lady and impressing them with his charming personality. (â€Å"Smallville†) He is also sometimes seen playing the piano, where he intentionally lets people see the soft and refined side of him. Oliver have the kind of personality that is not easily forgettable.When he enters a room, he make s a great impression on everyone with his charm and wit. He converses with just about anyone and his conversations are usually laced with humor. Compared to other wealthy billionaires, Oliver has become very down to earth and he does not let his status in society and wealth hinder him from ridding the world of evil. (â€Å"Appointment in Crime Alley†) As very powerful and handsome men, Apollo and Oliver’s lives are filled with women and their love interests are numerous. Unfortunately, their affairs never last or are always cut short by another factor.Philip Mayerson explained in his book of various relationships of Apollo. Apollo’s first love Castalia changed into a spring of water. His next love Cassandra, a Trojan Princess, was cursed by Apollo himself. Sibyl was granted her wish of living as long as the grains of sand in her hand, therefore becoming just a voice. Daphne turned into a tree nymph. His wife Coronis was burned to death. While Oliver’s lov ers did not have brutal endings like Apollo’s, Oliver still went through various women. He was in a relationship with Black Canary when they were working together for the Justice League.He later came across Shado, a Japanese assassin who was killing the yakuza, and had an affair with her. Oliver was also seen kissing a girl named Marianne now and then. (â€Å"Scott McCullar's Green Arrow Compendium†) Throughout his first appearance in Smallville, Oliver was seen dating Lois Lane, the future wife of Superman. They had differences that cannot be overcome and their relationship ended. After that, Oliver seemed to rekindle with an on-and-off old flame Tess Mercer, who was also Lex Luthor’s, Oliver’s enemy, ex-wife. She is also very cunning and self-perseverative.She only cared for herself and fled when Oliver came into trouble. She later came back to be a good friend and support system for the vigilante team. Oliver also had flings with Betsy Braddock and Adr ienne Frost. Betsy Braddock was noticed by Oliver because she had psychic abilities. Oliver came across Adrienne Frost because she seemed to have telepathic abilities. (â€Å"Smallville Season 6 – 10†) Oliver’s fascination with these two ladies especially reminded me of Apollo and his †¦. Oliver’s latest and last known relationship is with Chole Sullivan and they have a child together.While there are many similarities between Apollo and Oliver Queen, there are also several differences. Apollo is the God of Prophecy; therefore he or his oracles are prophetic and can know what will happen in the future. While their answers are ambiguous, the oracle or the priests who interpret them still seemed to predict well enough. (Mayerson 124) Among the superheroes, Oliver is one of the few people without any metahuman skills. He compensates it by improving his skills as well as trying to predict and be more aware of possible threats. He does this by using the Wa tchtower, along with a team of superheroes.The Watchtower is ran by Chloe Sullivan, his then-friend and now-wife. However, the equipment and research is funded by Oliver’s very own Queen Industries, whose support is very crucial. The Watchtower allowed Oliver’s Justice League to assess any incoming supernatural problems and patterns, observe happenings in the world, and access almost any paperless trails. (â€Å"Watchtower†) In Classical Mythology in Literature, Art, and Music, Philip Mayerson states that Apollo is â€Å"a god of Purification, particularly from acts, such as homicide†. On the other hand, Oliver does not have a problem with stealing and murdering.It does not necessarily make him a bad man. Oliver decided use his improved archery skills to become a vigilante. This requires him to defeat and overcome opponents who were very similar to the man he used to be. He thwarts greed and corruption from hurting average citizens. He channels a modern d ay Robin Hood persona and constantly fights for underdogs. Since his days stuck on the island was full of misery, sweat, blood, and desperation, he came to understand the â€Å"testament to what it takes for someone to answer that wake-up call, change their ways, and fly straight. As straight as an arrow. (â€Å"Green Arrow†) While Apollo and Oliver Queen both went through various relationships and affairs, there is one major difference between them. Apollo dearly loved Coronis but was worried she might not stay faithful him. She did not, and he or his sister Artemis punished her transgression by setting her on fire. Apollo â€Å"regretted the hasty action, but it was too late. † (Mayerson 131) Oliver, on the other hand, was much luckier. After going through many obstacles together as a crime-fighting team, Oliver finally realizes his love for Chloe, who already seems to be in love with him as well.In â€Å"Warrior/ Super girl†, viewers can obviously see how co mpatible Oliver and Chloe are with each other. It was a beginning of a romance that changed their lives. They stopped hiding their feelings and kept no secrets. This lifted some weight off of Oliver’s shoulders since he does not have to hide his secret identity as Green Arrow from her either. Unfortunately, their relationship was tested with various situations, such as both of them sacrificing themselves into enemies’ hands and going far away to keep the other one safe. However, they just cannot stand to be apart from each other.During the episode called â€Å"Fortune†, they happily married in the tenth and final season of Smallville television series. Oliver tells her â€Å"You saved my life, Chloe. Both the myth and the man. † (â€Å"KSite TV†) There are many similarities and differences between the Greek god Apollo and the television show character Oliver Queen. Despite their various statuses situations, they both are powerful men, who went thro ugh many heartaches and obstacles. They are so different yet so alike. This is why I believe that Apollo and Oliver makes a very good comparison to each other.

My Community Internship Experience

The aim of this community internship program is for us to provide knowledge and practical experience necessary for functioning competently and effectively upon licensee in a health-system pharmacy. As a first year pharmacy student, I feel so nervous before entering into this kind of internship because I don't know what will happen when I'm into it and what will be the possible effect, but I'm really glad when I finished the required number of hours because all the hard work and sacrifices has paved off.During my internship period In MD-Rosary I experienced a lot Like organizing of drugs and arranging It to Its respective gondola, paper tabulating, dispensing, and more that Is not being practiced at the school. During our first day at MO-Rosaries they introduced to us the rules and regulations of the drugstore from the signing of DART before we leave and enter the store and also the body search overtime we leave the store, then after that Ma'am Carol showed the Rag area to us hen we s tarted copying the drugs In the Rag area after that we roam around and observed the whole drugstore.The next day we do the same thing as well, and we started copying each book from book 1 to 10 till the last day of our internship and we are always having an exam per book weekly. The best experience in this internship is when we were permitted to dispense drugs and at the same time we encounter different kinds of customers. I'm grateful that I finished this internship and learned a lot that will lead me too brighter future.

Carol Sheriff’s The Artificial River Essay

APUS, Section 4 Mr. Gordinier January 8th, 2013 All situations and topics have multiple views and perspectives to them. A paradox exhibits contradictory aspects in which there is not either a single good or a bad, positive or negative. In The Artificial River The Erie Canal and the Paradox of Progress, 1817-1862, written by Carol Sheriff, there are many different examples of paradoxes. Towns initially saw the Canal having a negative impact on them, but realized it could help. The Canal provided for faster transportation, but in the case of a crash would take a long time to recover from. Also businessmen benefitted from the Canal, but other lost a lot of money because of it. The Canal provided dramatic change to the upstate New York area. In some cases this change resulted in prosperity and in others it resulted in failure and loss. At the time prior to building the Canal many negative impacts were the only things being considered. In 1826, a Canal Board was set up to deal with many of these complaints and problems. Most of the agreements and compromises were expressed through contracts made between the Canal Board and the people of the towns. Individuals questioned the right to take land to build the canal, water resources being used, and also commercial structures being built along the Canal. The thought of how much these commercial structures could drastically benefit these towns were not contemplated. When the Canal was built towns all along the route from Buffalo to Albany prospered from the revenue and the attraction the Canal brought with it. Whether the Canal was being used for business people, immigrants, settlers of the region, or tourists, the border-towns all had some appeal to these persons. After some time the state was continually asked to expand the Canal from the original route to include connecting canal routes. However, the same towns along the route from Buffalo to Albany had already been established along the lines of the original canal. These towns would need to be relocated in order to obey these new requests. This presented a major problem because the people in these towns had formed a life around the Canal and many of them made their income based of the Canal. The inhabitants of the towns changed their mentality from not wanting the Canal to invade on their lives, to it being an essential part of their lives they depended upon. The Erie Canal provided an extremely fast source of transportation compared to other ones of that time. A lot of the land that the Canal went through was uninhabited and therefore people weren’t able to move through these areas. Once the Canal was built it served as that pathway through these areas. The Canal also was a much cheaper source of transportation that was used by residents, tourists, emigrants, and workers during this time. Evangelical preachers used the artificial river to seek salvation among these people. Also the Canal helped to serve as an underground railroad, transporting slaves from Syracuse to Buffalo, near the Canadian border (Sheriff 53). The Canal not only sped up transportation, but also cost much less for goods to be delivered. Before the Canal goods from Albany to Buffalo would increase to five or six times their actual value just because of transportation. This helped business prosper and served as a positive aspect for the Canal. Although transportation was faster if a boat along the Canal crashed it would hold things up for a long time. A boat crashing had a chain effect on other boats because they then would be slowed down as well. People would not get where they needed to be on time was well as goods. A lot of the times if a boat did crash the goods were not able to be salvaged and hurt the business that owned them. There was also the issue of passing under bridges and how low they were. In a play of William Dunlap the brother of Amelia describes the inconvenience this was saying â€Å"In constant dread of lifting your head above your knees for fear of having it knock’d off your shoulders by a bridge† (Sheriff 55). Inconveniences such as these eventually encouraged travelers to find a different source of transportation; the railroad. The railroad had advantage over the Canal in the fact that it could run all year round. Individuals took advantage of the Canal and used it to help themselves gain profit. Businessmen and entrepreneurs saw the Canal as an opportunity to make money. Some bought their own boats and turned them into their business place. Boats were transformed to stores and markets in which people would buy off of them. Business was not only done on the Canal, but other men would use all the people, especially tourists, and try to sell consumer goods to them. A lot of times these vendors would scam people buying from them. They would sell fake remedies with false claims. Many times they would also trade counterfeit bills for items of actual value. The Canal helped solo merchants in a way that had never been done before. On the other hand the Canal was also very detrimental to many people as well. The people it affected were those whose land and water supply it had taken. When the Canal was built it ruined early settlers property such as the Archbalds. Frequently properties were cut in half. Once water was let into the Canal it caused a number of problems. Majorly because of poor workmanship and laziness water would stream out of the Canal and into farmers’ land. Fields and basements would be flooded, livestock would be injured, and gardens would be damaged. Also the workers feet would trample over fields, showing no regard or carefulness of their surroundings. One farmer claimed that workers torn down his fence simply for their own amusement. Without a healthy stock of crops the farmers would not make as much money and financially were negatively affected by the Canal. The Erie Canal had widely varying results on the people it impacted. Businessmen and entrepreneurs received financial success through the Canal while farmers and people already established along the lines of the Canal seemed to be negatively affected by it. There is no question transportation was faster and cheaper than any other source around that time. Communities and towns both benefitted from the Canal being around them. Initially there was a great amount of hype surrounding the Canal and all this hype brought people. Businesses thrived off these tourists and newcomers. Positives and negatives came from the opening of the artificial river that would change history forever.

Desktop and Laptop Computers Marketing in Philippines Essay

Desktop and Laptop Computers Marketing in Philippines - Essay Example In the website of CIA-The world fact book (2007) it is stated that "The Philippine Islands became a Spanish colony during the 16th century; they were ceded to the US in 1898 following the Spanish-American War. In 1935 the Philippines became a self-governing commonwealth. Manuel QUEZON was elected president and was tasked with preparing the country for independence after a 10-year transition. In 1942 the islands fell under Japanese occupation during WWII, and US forces and Filipinos fought together during 1944-45 to regain control. On 4 July 1946 the Republic of the Philippines attained its independence." In dealing with this statement alone, it would give us the idea of chances in penetrating the market, since our country has made significant change in this Arizona-sized country. Despite the fact that the country is the second poorest nation in Asia (Next to Bangladesh), the country showed significant demands on the acquisition and utilization of desktop and laptop computers since the country is gearing for the digitalization of all of the offices and industries and with this events, utilization of computers is one of the need of this country. Furthermore, the world fact book of CIA described the economic overview of the country as "The Philippines was less severely affected by the Asian financial crisis of 1998 than its neighbors, aided in part by its high level of annual remittances from overseas workers, no sustained runup in asset prices, and more moderate debt, prior to the crisis. From a 0.6% decline in 1998, GDP expanded by 2.4% in 1999, and 4.4% in 2000, but slowed to 3.2% in 2001 in the context of a global economic slowdown, an export slump, and political and security concerns. Average GDP growth accelerated to about 5% between 2002 and 2006 reflect ing the continued resilience of the service sector, and improved exports and agricultural output" This kind of situation gave us enough grounds to consider that this country has the money and resources to purchase such goods. In order to further determine that the market has enough resources to shell out and to be able to determine that the product would be a hit for this country, using Hofstede's Five Dimensions of Culture as a parameter is a good pendulum to analyze the capability of this country in a cultural perspective as well as comparing it to US are important factors to be analyzed. International Marketing 3 The first thing that we should consider is the Power distance index (PDI) of the Philippines. Based on the research conducted by several non government organization and voluntary group, there is a huge distance between the rich and the poor from this country. Unanimously, these organizations concluded that less than 10 percent of the families are included in the so-called upper class of the society (the rich and famous) and the remaining 90 belongs to the B,C and D classes of the society. Among these classes, the class C and D are the ones who are the majority. In this case, it is established that the rich and the famous does have distance with each other and such a scenario suggests imbalance since less than 10 percent of the population are wealthy and the poor ones does have grater

Overt Police Patrol Essay Example | Topics and Well Written Essays - 2500 words

Overt Police Patrol - Essay Example Over the past forty years, police activities and policies have been a realm of extensive review and reform in UK, particularly in England and Wales. These extensive review and reform called for community policing, police accountability, police response to public disaster and crime, and the impact of public perception of police on the media. The study of Sharp (2005) suggests that there is a need for a better understanding of the theories that apply to police practice in general. Similarly, there is a relevance and applicability of recent theoretical developments in British surveillance studies, supporting how policing activities may be made effective. In this sense, the surveillance solution occupies the central stage in the midst of new policy initiatives for an attempt to modernize the criminal justice system (Clive 2006). Crawford (1999) analyzed current criminal justice discourses and practices relating to the actions in the community, as well as prevention and partnerships. Impo rtant subject matters that influence the strength of overt police patrol in countering and reducing crimes are government strategies originating from both the state and outside it (ibid). These strategies reflect the extent to which sociopolitical landscape may be transformed in connection with crime control and prevention. Police accountability has been consider... crimes in the UK, after the killing of an innocent man, Jean Charles de Menezes who was wrongly suspected as a suicide bomber by the Metropolitan Police. Traditional policing in the UK have been based on the construct of reasonableness, compromise, and respect for the individual's rights, in which a central tenet is the rare use of coercive force, premised on the continuum that ranges from negotiation to lethal consequences (Kennison and Loumansky 2007). Developed policies in order to combat crimes and terrorism denote a preferred option to restrict police to shoot to kill. There is a general consensus that a robust and overt response are required to combat terrorism and crimes, thus, a balance among liberty, security, and police accountability is an issue raised (ibid). It implies that overt police activities have a corresponding requirement for accountability, which is assessed in the context of operational policy-making. Kennison and Loumansky conclude that the nature and structur e of policing is transforming from being covert, reasonable, and understated towards zero tolerance, military, and overt style in the quest to combat terrorist crimes. It implies that traditional reactive policing styles have given way to a proactive military style with overt displays, which tend to overlook civil rights. Hence, there is a need for the public to trust their police, because a trustworthy police system is one that acknowledges the civil rights of people. In its annual report (2004-2005), Hampshire Police Authority stressed that a year of rapid growth in its capacity to meets its objectives in terms of policing has transpired with the appointment of a Community Consultation Officer and a Performance Officer. In 2000, challenging targets were set in reducing domestic

LABOUR MARKET POLICY The essay should be a maximum of 1400 words in

LABOUR MARKET POLICY The should be a maximum of 1400 words in length - Essay Example Since the agent represents the persona of the company, principles should selectively hire agents that can best represent their agenda. This relationship can be ideal when the agent is an expert in the field and displays allegiance to the principle. However, if overall goals aren’t uniformed then problems can arise. In order to minimize misunderstandings, informal or formal contracts, that explain what is expected of the agent, should be given to the agent and firmly enforced. The principle should ensure that vital language is inserted in the agreement to protect and promote the principle’s agenda. For corporations, which are your larger principles, human resource managers should be hired to maximize employee output. Authors David E Dimick and Victor V. Murray (1978: 611) in their article â€Å"Correlates of Substantive Policy Decisions in Organizations: The Case of Human Resource Management† defines human resource managers as personnel management which facilitate various organizational objectives. One responsibility of the human resource manager is the implementation of personnel practices that fit the specific needs of the employer. The human resource managers are directly responsible for the hiring of most qualified employees that display the most appropriate levels of capabilities. Thus the human resource manager should act in the best interest of the principle and formulate agency policy that benefits the behalf of the principle. Since human resource managers act as intermediaries between the corporate principle and agent, they should have in-depth knowledge of specific task demands. Knowing what is needed to ensure flow of operations, human resource managers should modify agency policy to include clear language to the agent of the expectations to their duties and expectations of the principle. According to the authors Lee G. Bolman and Terrence E. Deal